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The Ke Yuan lab at Boston Children's Hospital and Harvard Medical School will dissect the critical role of pericytes during angiogenesis and aim to understand abnormal vascular remodeling in pulmonary arterial hypertension (PAH) and other pulmonary vascular diseases. The ultimate goal is to identify potential therapeutic targets that could be exploited for the development of new drugs capable of preventing abnormal vessel remodeling and obliteration in PAH.

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Congratulations to Hyunbum Kim, YuLiu, JiwonKim, Yunhye Kim and Timothy Klouda on the new research paper published in EMBO reports, entitled " Pericytes contribute to pulmonary vascular remodeling via HIF2α signaling".  These findings Study suggest hypoxia overexpression causes pericytes to contribute to pulmonary hypertension.

This study also headlines on Boston Children's Hospital here https://answers.childrenshospital.org/pericytes-and-vascular-remodeling/

Please check out this article as a PDF here https://www.embopress.org/doi/epdf/10.1038/s44319-023-00054-w

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